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KMID : 0903519940370020105
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1994 Volume.37 No. 2 p.105 ~ p.109
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Tumor cell growth inhibition and antioxydative activity of flavonoids from the stem bark of Cudrania tricuspidata
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김창진/Kim, Chang Jin
송경식/유익동/이인경/김환묵/오구택/Song, Kyung Sik/Yoo, Ick Dong/Lee, In Kyoung/Kim, Hwan Muk/Oh, Goo Taeg
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Abstract
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Five cytotoxic and antioxidative flavonoids were isolated from the stem bark of Cudrania tricuspidata by consecutive purification using HP-20, silicagel and prep-HPLC. They were identified as taxifolin, orobol, eriodictyol, dihydrokaempferol and steppogenin by means of spectral studies. The antioxidative activities (IC_(50)) assayed by TBA method of these compound 1∼5 to were 6, 3, 3, $gt;50, and 10 ㎍/㎖, respectively. The effect on the growth inhibition (IC_(50)) of these compounds against P388 cell line were found to be 0.18, 3.3, 15 and 6.2 ㎍/㎖, respectively in the order of compound 2 to 5.
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